Correction to “Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model”
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ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to “Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model”André HoratscheckAndré HoratscheckMore by André Horatscheck, Ana AndrijevicAna AndrijevicMore Andrijevic, Aloysius T. NchindaAloysius NchindaMore Nchinda, Claire Le ManachClaire ManachMore Manachhttp://orcid.org/0000-0002-9310-0048, Tanya PaquetTanya PaquetMore Paquet, Lutete Peguy KhondeLutete KhondeMore Khonde, Jean DamJean DamMore Dam, Kailash PawarKailash PawarMore Pawar, Dale TaylorDale TaylorMore Taylor, Nina LawrenceNina LawrenceMore Lawrence, Christel BrunschwigChristel BrunschwigMore Brunschwig, Liezl GibhardLiezl GibhardMore Gibhard, Mathew NjorogeMathew NjorogeMore Njorogehttp://orcid.org/0000-0003-1276-2224, Janette ReaderJanette ReaderMore Reader, Mariëtte van der WattMariëtte WattMore Watt, Kathryn WichtKathryn WichtMore Wicht, Carolina C. de SousaAna SousaMore Sousa, John OkomboJohn OkomboMore Okombo, Keletso MaepaKeletso MaepaMore Maepa, Timothy J. EganTimothy EganMore Eganhttp://orcid.org/0000-0001-7720-8473, Lyn-Marie BirkholtzLyn-Marie BirkholtzMore Birkholtz, Gregory S. BasarabGregory BasarabMore Basarab, Sergio WittlinSergio WittlinMore Wittlin, Paul V. FishPaul FishMore Fishhttp://orcid.org/0000-0002-2117-2173, Leslie StreetLeslie StreetMore Street, James DuffyJames DuffyMore Duffy, Kelly Chibale*Kelly ChibaleMore Chibalehttp://orcid.org/0000-0002-1327-4727Cite this: Med. Chem. 2021, 64, 3, 1762Publication Date (Web):January 28, 2021Publication History Published online28 January 2021Published inissue 11 February 2021https://doi.org/10.1021/acs.jmedchem.1c00064Copyright © 2021 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views787Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated reflect usage leading up last few days.Citations number other articles citing this article, calculated Crossref daily. Find more information about citation counts.The Altmetric Attention Score quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com additional details score social media presence for given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InReddit (394 KB) Get e-Alerts
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Protein complex directs hemoglobin-to-hemozoin formation in Plasmodium falciparum.
Malaria parasites use hemoglobin (Hb) as a major nutrient source in the intraerythrocytic stage, during which heme is converted to hemozoin (Hz). The formation of Hz is essential for parasite survival, but to date, the underlying mechanisms of Hb degradation and Hz formation are poorly understood. We report the presence of a ∼200-kDa protein complex in the food vacuole that is required for Hb d...
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ژورنال
عنوان ژورنال: Journal of Medicinal Chemistry
سال: 2021
ISSN: ['0022-2623', '1520-4804']
DOI: https://doi.org/10.1021/acs.jmedchem.1c00064